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Brain neurotransmitter serotonin is involved in the regulation of many physiological functions and types of behavior. The key enzyme of serotonin synthesis in the brain is tryptophan hydroxylase-2 (TPH-2). Linkage between the C1473G polymorphism in gene tph2 causing the replacement of Pro447 by Arg447 in TPH-2 molecule and enzyme activity in the mouse brain of 10 inbred strains was found. Association of the polymorphism with the TPH-2 activity in the brain of F2 hybrids between strains C57BL/6 and CC57BR was shown. The results indicate that the C1473G polymorphism in gene tph2 is the main factor determining the genetically defined variability of enzyme activity in the mouse brain.
I've been trying to find somewhere to comment on the taxobox '?' link to "How to read a taxobox", and I hope this is the right place. The page explaining a taxobox is very clear and helpful, even though I knew that the taxobox was obviously showing the taxonomy. I just found the random '?' to be a bit confusing. It is not clear what it is, and you have to click on it, or hover the mouse cursor over it, to find out what it is. Would it not be better to have the link as a superscript note to the Scientific classification link in the taxobox? This would also solve the problem you are discussing above. Or to have a heading for the taxoboxes saying what they are, and to have the link there instead? Essentially, I am saying that I think the '?' link is unecessary and distracting to those who know what a taxobox is, and it is mysterious and confusing (never seen a '?' sign used this way before in wikipedia) to those who might think of clicking on it. 194.200.237.219 10:46, 5 October 2005 (UTC)Reply[reply]
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